DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’
نویسندگان
چکیده
منابع مشابه
Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer
It is now clear that human neoplasms form, progress, and respond to therapy in the context of an intimate crosstalk with the host immune system. In particular, accumulating evidence demonstrates that the efficacy of most, if not all, chemo- and radiotherapeutic agents commonly employed in the clinic critically depends on the (re)activation of tumor-targeting immune responses. One of the mechani...
متن کاملEvaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses
When cells die by necrosis in vivo they stimulate an inflammatory response. It is thought that this response is triggered when the injured cells expose proinflammatory molecules, collectively referred to as damage associated molecular patterns (DAMPs), which are recognized by cells or soluble molecules of the innate or adaptive immune system. Several putative DAMPs and/or their receptors have b...
متن کاملCorrection: Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses
Dr. Yoshitaka Kimura should be included in the author byline. Dr. Kimura should be listed as the fourth author, and is affiliated with 2: the Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan and with the Department of Allergy and Rheumatology, the University of Tokyo Graduate School of Medicine. The contributions of this author are as follows: conceived and de...
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Ageing has pronounced effects on the immune system, including on innate immune cells. Whilst most studies suggest that total numbers of different innate immune cell populations do not change dramatically during ageing, many of their functions such as phagocytosis, antigen presentation and inflammatory molecule secretion decline. In contrast, many endogenous damage-associated molecular patterns ...
متن کاملDiabetes mellitus, hypertension and ageing: the ionic hypothesis of ageing and cardiovascular-metabolic diseases.
Ageing in industrialised societies is associated with an increasing prevalence of hypertension, atherosclerotic vascular diseases, reduced insulin sensitivity and non-insulin-dependent diabetes mellitus (NIDDM). It has been suggested that hyperinsulinaemia/insulin resistance and/or hyperglycaemia could play a role in determining and/or exacerbating the hypertension and vascular disease associat...
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ژورنال
عنوان ژورنال: Ageing Research Reviews
سال: 2015
ISSN: 1568-1637
DOI: 10.1016/j.arr.2014.10.004